Revision with unchanged content. A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called recombination. A genealogy involving recombination is best described by a network structure. A more general approach was implemented in a new computational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombination events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.
Produktkennzeichnungen
EAN
9783639452273
ISBN
9783639452273
ISBN-10
3639452275
ISBN-13
9783639452273
eBay Product ID (ePID)
165921236
Produkt Hauptmerkmale
Produktart
Lehrbuch
Sprache
Englisch
Anzahl der Seiten
208 Seiten
Verlag
AV Akademikerverlag
Publikationsname
Phylogenetic Analysis of Viral Quasispecies
Autor
Patricia Buendia
Format
Taschenbuch
Erscheinungsjahr
2012
Maße
Gewicht
292g
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Paperback
Item Length
22cm
Item Height
1cm
Item Width
15cm
Sprachausgabe
Englisch
Seiten
208 Seiten
Item Weight
328g
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