This study examined the determinants of effective implementation of Artisan and Craft courses in Catholic sponsored community colleges in Nairobi region, Kenya. The study was underpinned in two theoretical orientations and adopted the mixed methods research design. The study sample comprised 18 Artisan and Craft teachers and 172 Artisan and Craft students and four directors of Catholic sponsored community colleges. The study triangulated questionnaires and interview guides which were content-and face-validated and reliability was determined using Cronbach's alpha. The study established that attitude of teachers and students, teaching strategies, adequacy of teaching and learning resources, teacher motivation, teaching workload and attending of in-service courses had a high influence on the implementation of Artisan and Craft curriculum. On the contrary, industrial attachment, field practice and college-community collaborations were found to have a low influence on the implementation of Artisan and Craft curriculum.