This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits Aß aggregation and examine recent results from in vivo experiments where BRICHOS inhibits Aß aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature¿s (more specific) ways to protect against fibril formation, and exploring the potential of using the BRICHOS domain in the fight against Alzeimer's Disease and other amyloid diseases seems highly relevant. This brief is useful for newcomers to this field or researchers in related fields wishing to gain a quick overview of the latest findings.
Produktkennzeichnungen
ISBN-10
3319165631
ISBN-13
9783319165639
eBay Product ID (ePID)
211388924
Produkt Hauptmerkmale
Sprache
Englisch
Anzahl der Seiten
Xv Seiten
Verlag
Springer-Verlag Gmbh, Springer International Publishing
Publikationsname
The Brichos Domain
Autor
Jenny Presto
Format
Taschenbuch
Erscheinungsjahr
2015
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Book
Item Length
23cm
Item Height
10mm
Item Width
15cm
Mitautor
Jan Johansson
Item Weight
109g
Buchreihe
Springerbriefs in Molecular Science
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