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Pharmazeutische Biotechnologie von Carlos A Guzman: Neu-

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Pharmaceutical Biotechnology by Carlos A Guzman: New
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Artikelzustand
Neu: Neues, ungelesenes, ungebrauchtes Buch in makellosem Zustand ohne fehlende oder beschädigte ...
Publisher
Springer New York
Publication Date
2009-08-01
Pages
256
Author
Giora Z. Feuerstein
ISBN
9781441911315
EAN
9781441911315
Subject Area
Science, Medical
Publication Name
Pharmaceutical Biotechnology
Item Length
9.3 in
Subject
Pharmacy, Research, Chemistry / Organic
Series
Advances in Experimental Medicine and Biology Ser.
Publication Year
2009
Type
Textbook
Format
Hardcover
Language
English
Item Width
6.1 in
Item Weight
21 Oz
Number of Pages
276 Pages

Über dieses Produkt

Product Information

Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives--basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins andvaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens' genomes provides opportunities that never before have been available--identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated,replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.

Product Identifiers

Publisher
Springer New York
ISBN-10
1441911316
ISBN-13
9781441911315
eBay Product ID (ePID)
109297780

Product Key Features

Author
Giora Z. Feuerstein
Publication Name
Pharmaceutical Biotechnology
Format
Hardcover
Language
English
Subject
Pharmacy, Research, Chemistry / Organic
Series
Advances in Experimental Medicine and Biology Ser.
Publication Year
2009
Type
Textbook
Subject Area
Science, Medical
Number of Pages
276 Pages

Dimensions

Item Length
9.3 in
Item Width
6.1 in
Item Weight
21 Oz

Additional Product Features

LCCN
2009-024877
Intended Audience
Scholarly & Professional
Series Volume Number
655
Number of Volumes
1 Vol.
Lc Classification Number
Rs400-431
Table of Content
Translational Medicine--A Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers.- Natural Products in Drug Discovery: Present Status and Perspectives.- Protein Pharmaceuticals: Discovery and Preclinical Development.- The Role of Nanobiotechnology in Drug Discovery.- Conotoxin Venom Peptide Therapeutics.- Shark Novel Antigen Receptors--The Next Generation of Biologic Therapeutics?.- Immune Interventions of Human Diseases through Toll-Like Receptors.- Genome-Based Vaccine Development: A Short Cut for the Future.- The Antigenome: From Protein Subunit Vaccines to Antibody Treatments of Bacterial Infections?.- HSV as a Vector in Vaccine Development and Gene Therapy.- Virus-Like Particles as a Vaccine Delivery System: Myths and Facts.- Applications of Bacterial Ghosts in Biomedicine.- Immune Modulators with Defined Molecular Targets: Cornerstone to Optimize Rational Vaccine Design.- Innovative Approaches to Develop Prophylactic and Therapeutic Vaccines against HIV/AIDS.- New Strategies to Overcome the Drawbacks of Currently Available Flu Vaccines.
Copyright Date
2009
Dewey Decimal
615/.19
Dewey Edition
22
Illustrated
Yes

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