Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.
Produktkennzeichnungen
ISBN-10
3540794611
ISBN-13
9783540794615
eBay Product ID (ePID)
70241929
Produkt Hauptmerkmale
Produktart
Lehrbuch
Sprache
Englisch
Anzahl der Seiten
104 Seiten
Verlag
Springer Berlin Heidelberg, Springer Berlin
Publikationsname
The Subthalamic Nucleus
Autor
Tjitske Heida
Format
Taschenbuch
Erscheinungsjahr
2008
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Paperback
Item Length
23cm
Item Height
5mm
Item Width
15cm
Nummer Innerhalb der Serie
199
Mitautor
Kamen G. Usunoff, Enrico Marani
Item Weight
172g
Buchreihe
Advances in Anatomy, Embryology And Cell Biology
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