It covers all aspects of DC generation, function, survival and antitumor activity in the tumor environment both in vivo and in experimental in vitro systems. The goal in focusing on a spectrum of issues related to DC in cancer is to provide an extensive and expansive review rather than a collection of independent analyses from different authors. Specific topics to be covered include analysis of DC behavior in the tumor microenvironment, including endogenous and exogenous DC, multiple DC populations, molecular pathways responsible for DC dysfunction, tumor-derived factors altering DC polarization and activation, mechanisms of DC alterations, and the role of DC in tumor escape from immune recognition and elimination. Furthermore, additional chapters provide extensive analysis of the consequences of cancer therapy on the DC system and how aging impacts DC function in the tumor microenvironment. Finally, chapters are included examining strengths and pitfalls of current methodologies for generating DC from cancer patients for therapeutic purposes and on the role of tumor-mediated modulation of the DC system in cancer immunotherapy.
Produktkennzeichnungen
Herausgeber
Russell D. Salter, Michael R. Shurin
ISBN-10
0387886109
ISBN-13
9780387886107
eBay Product ID (ePID)
72891492
Produkt Hauptmerkmale
Sprache
Englisch
Anzahl der Seiten
Xviii Seiten
Verlag
Springer-Verlag Gmbh, Springer Us
Publikationsname
Dendritic Cells in Cancer
Autor
Michael R. Shurin, Russell D. Salter
Format
Gebundene Ausgabe
Erscheinungsjahr
2009
Zusätzliche Produkteigenschaften
Hörbuch
No
Item Length
24cm
Item Height
3cm
Item Width
16cm
Item Weight
753g
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