Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.
Produktkennzeichnungen
Herausgeber
Thomas E. Lane
ISBN-10
3540292071
ISBN-13
9783540292074
eBay Product ID (ePID)
4309040
Produkt Hauptmerkmale
Produktart
Lehrbuch
Sprache
Englisch
Anzahl der Seiten
176 Seiten
Verlag
Springer Berlin Heidelberg, Springer Berlin
Publikationsname
Chemokines And Viral Infection
Autor
Thomas E. Lane
Format
Gebundene Ausgabe
Erscheinungsjahr
2006
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Hc Runder Rücken Kaschiert
Item Length
24cm
Item Height
1cm
Item Width
16cm
Nummer Innerhalb der Serie
303
Buchreihe
Current Topics in Microbiology And Immunology
Item Weight
468g
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