SynopsisAn overview of the theory and application of linear and nonlinear mixed-effects models in the analysis of grouped data, such as longitudinal data, repeated measures, and multilevel data. The authors present a unified model-building strategy for both models and apply this to the analysis of over 20 real datasets from a wide variety of areas, including pharmacokinetics, agriculture, and manufacturing. Much emphasis is placed on the use of graphical displays at the various phases of the model-building process, starting with exploratory plots of the data and concluding with diagnostic plots to assess the adequacy of a fitted model. The NLME library for analyzing mixed-effects models in S and S-PLUS, developed by the authors, provides the underlying software for implementing the methods presented. This balanced mix of real data examples, modeling software, and theory makes the book a useful reference for practitioners who use, or intend to use, mixed-effects models in their data analyses. It can also be used as a text for a one-semester graduate-level applied course., This book provides an overview of the theory and application of linear and nonlinear mixed-effects models in the analysis of grouped data, such as longitudinal data, repeated measures, and multilevel data. Over 170 figures are included in the book., Mixed-e'ects models provide a ?exibleand powerful toolfor theanalysis of grouped data, which arise in many areas as diverse as agriculture, biology, economics, manufacturing, and geophysics. Examples of grouped data - clude longitudinal data, repeatedmeasures, blocked designs, and multilevel data. The increasing popularity of mixed-e'ects models is explained by the ?exibility they o'er in modeling the within-group correlation often present in grouped data, by the handling of balanced and unbalanced data in a uni'ed framework, and by the availability of reliable and e'cient software for ?tting them. This book provides an overview of the theory and application of l- ear and nonlinear mixed-e'ects models in the analysis of grouped data. A uni'ed model-building strategy for both linear and nonlinear models is presentedandappliedtotheanalysisofover20realdatasetsfromawide- riety of areas, including pharmacokinetics, agriculture, and manufacturing. A strong emphasis is placed on the use of graphical displays at the various phases of the model-building process, starting with exploratory plots of the data and concluding withdiagnostic plots toassess the adequacy of a ?tted model. Over 170 ?gures are included in the book.
LC Classification NumberQA276-280