Produktinformation
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.Produktkennzeichnungen
HerausgeberThomas E. Lane
ISBN-103540292071
ISBN-139783540292074
eBay Product ID (ePID)4309040
Produkt Hauptmerkmale
VerlagSpringer Berlin Heidelberg, Springer Berlin
Erscheinungsjahr2006
Anzahl der Seiten176 Seiten
PublikationsnameChemokines And Viral Infection
SpracheEnglisch
ProduktartLehrbuch
AutorThomas E. Lane
ReiheCurrent Topics in Microbiology And Immunology
Zusätzliche Produkteigenschaften
HörbuchNo
InhaltsbeschreibungHc Runder Rücken Kaschiert
Nummer Innerhalb der Serie303
Item Height1cm
Item Length24cm
Item Weight468g