Produktinformation
Obesity is a recently established risk factor for breast cancer. A characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin. Evidence indicates leptin plays an important role in breast cancer development and progression; however the mechanisms involved are poorly understood. Towards better defining the role of leptin in breast cancer, herein we describe the identification of leptin-regulated genes and proteins in hormone responsive MCF-7 human breast cancer cells. Leptin significantly increased the proliferation and protein secretion in MCF-7 cells. The effect of leptin in modulating the extracellular environment and inhibiting apoptosis was also determined. These data suggest leptin regulates mammary tumor cell behavior through multiple mechanisms. In addition to regulating mitogenic cell signaling pathways, leptin influences mammary tumor cell growth by regulating apoptosis, cell cycle, secretion of autocrine/ paracrine factors and modulating the extracellular environment. Identification of leptin-regulated factors provides valuable mechanistic links into the relationship between obesity and breast cancer.Produktkennzeichnungen
EAN9783838373331
ISBN9783838373331, 3838373332
ISBN-103838373332
ISBN-139783838373331
eBay Product ID (ePID)162518301
Produkt Hauptmerkmale
VerlagLap Lambert Academic Publishing
Erscheinungsjahr2010
Anzahl der Seiten128 Seiten
PublikationsnameMechanisms of Leptin in Breast Cancer Development And Progression
SpracheEnglisch
ProduktartLehrbuch
AutorCandida Perera, Ignacio Camarillo
FormatTaschenbuch
Zusätzliche Produkteigenschaften
HörbuchNo
SprachausgabeEnglisch
MitautorIgnacio Camarillo
InhaltsbeschreibungPaperback
Seiten128 Seiten
Item Height8mm
Item Length22cm
Item Weight209g