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Glucagon I von T.T. Aoki (englisch) Taschenbuch Buch-

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Glucagon I by T.T. Aoki (English) Paperback Book
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Zuletzt aktualisiert am 29. Jan. 2025 01:15:48 MEZAlle Änderungen ansehenAlle Änderungen ansehen

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ISBN-13
9783642688683
Book Title
Glucagon I
ISBN
9783642688683

Über dieses Produkt

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
3642688683
ISBN-13
9783642688683
eBay Product ID (ePID)
144006145

Product Key Features

Number of Pages
Xxx, 536 Pages
Publication Name
Glucagon I
Language
English
Subject
Life Sciences / Biochemistry, Pharmacy, Pharmacology
Publication Year
2011
Type
Textbook
Author
T. T. Aoki
Subject Area
Science, Medical
Series
Handbook of Experimental Pharmacology Ser.
Format
Trade Paperback

Dimensions

Item Height
0.5 in
Item Weight
34.8 Oz
Item Length
9.6 in
Item Width
6.7 in

Additional Product Features

Intended Audience
Scholarly & Professional
Series Volume Number
66 / 1
Number of Volumes
1 vol.
Illustrated
Yes
Table Of Content
Chemistry and Physicochemistry of Glucagon.- 1 Chemical Characteristics of Glucagon.- 2 The Chemical Synthesis of Glucagon.- 3 The Conformation of Glucagon.- Morphology of the A-cell of Islets of Langerhans, Biosynthesis of Glucagon and Related Peptides.- 4 Glucagon- and Glicentin-Producing Cells.- 5 Ontogeny and Phylogeny of the Glucagon Cell.- 6 The Biosynthesis of Glucagon.- 7 Glucagon, Glicentin, and Related Peptides.- Production and Assay of Glucagon.- 8 Glucagon Preparations.- 9 The Immunogenicity of Glucagon.- 10 Immunoassays for Glucagon.- 11 Heterogeneity of Circulating Glucagon and Glucagon-Like Immunoreactivity.- 12 Radioreceptorassays for Glucagon.- Actions of Glucagon.- 13 The Actions of Glucagon at Its Receptor: Regulation of Adenylate Cyclase.- 14 Glucagon and Liver Glycogen Metabolism.- 15 Glucagon and Gluconeogenesis.- 16 Glucagon and Liver Glucose Output In Vivo.- 17 Glucagon and Ketogenesis.- 18 Glucagon and Amino Acid Metabolism.- 19 Glucagon and Adipose Tissue Lipolysis.- 20 Glucagon and Lipoprotein Metabolism.- 21 Glucagon and Liver Regeneration.- 22 Glucagon and Insulin Secretion.
Synopsis
The Editorial Board of the Handbook of Experimental Pharmacology apparently did not hurry in suggesting production of a volume on glucagon since the present opus is number sixty-six in the series. This fact is even more striking if we consider that 34 volumes published over about eight years will separate the books on glucagon from those on insulin on library shelves, whereas only a few microns separate the cells manufacturing these two polypeptides within the islets of Langerhans in the pancreas! Numerous factors have probably caused this dicrimination; four of them are: First, insulin deficiency or resistance is the cause of one of the most serious and distressing diseases, diabetes mellitus, which affects millions of people, whereas glucagon deficiency is apparently an extremely rare disorder, for which detailed reports are published of individual cases whenever they occur. Second, since its discovery in 1921 by BANTING and BEST, insulin has been irreplaceable for the treatment of the most severe forms of diabetes, whereas, in contrast, glucagon was until recently considered a relatively minor therapeutic agent. Third, whereas insulin is a compound which has been well characterized since the pioneering work of SANGER and its biosynthesis clearly identified by STEINER and his co-workers, glucagon, also well characterized chemically, has suffered from its parenthood with the so-called "glucagon-like immunoreactive substances", an incompletely defined series of immunologically related polypeptides present in the gut, the pancreas and some other parts of the body., The Editorial Board of the Handbook of Experimental Pharmacology apparently did not hurry in suggesting production of a volume on glucagon since the present opus is number sixty-six in the series. This fact is even more striking if we consider that 34 volumes published over about eight years will separate the books on glucagon from those on insulin on library shelves, whereas only a few microns separate the cells manufacturing these two polypeptides within the islets of Langerhans in the pancreas Numerous factors have probably caused this dicrimination; four of them are: First, insulin deficiency or resistance is the cause of one of the most serious and distressing diseases, diabetes mellitus, which affects millions of people, whereas glucagon deficiency is apparently an extremely rare disorder, for which detailed reports are published of individual cases whenever they occur. Second, since its discovery in 1921 by BANTING and BEST, insulin has been irreplaceable for the treatment of the most severe forms of diabetes, whereas, in contrast, glucagon was until recently considered a relatively minor therapeutic agent. Third, whereas insulin is a compound which has been well characterized since the pioneering work of SANGER and its biosynthesis clearly identified by STEINER and his co-workers, glucagon, also well characterized chemically, has suffered from its parenthood with the so-called "glucagon-like immunoreactive substances", an incompletely defined series of immunologically related polypeptides present in the gut, the pancreas and some other parts of the body.
LC Classification Number
RM300-666

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