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RYANODINE RECEPTORS : STRUCTURE, FUNCTION & DYSFUNCTION
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- Sofort-KaufenRYANODINE RECEPTORS : STRUCTURE, FUNCTION & DYSFUNCTION
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US $6,47 (ca. EUR 5,57) USPS Media MailTM.
Standort: Sterling, Colorado, USA
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eBay-Artikelnr.:361144779811
Artikelmerkmale
- Artikelzustand
- Book Title
- RYANODINE RECEPTORS : STRUCTURE, FUNCTION & DYSFUN
- Intended Audience
- Adults
- Subject
- Medical
- ISBN
- 9780387231877
Über dieses Produkt
Product Identifiers
Publisher
Springer
ISBN-10
0387231870
ISBN-13
9780387231877
eBay Product ID (ePID)
43451984
Product Key Features
Number of Pages
Xxi, 330 Pages
Language
English
Publication Name
Ryanoidine Receptors : Structure, Function and Dysfunction in Clinical Disease
Publication Year
2004
Subject
Pharmacology, Cardiology
Type
Textbook
Subject Area
Medical
Series
Developments in Cardiovascular Medicine Ser.
Format
Hardcover
Dimensions
Item Weight
52.6 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2004-058942
Dewey Edition
22
Series Volume Number
254
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
612.3/924
Table Of Content
Evolution of the Ryanodine Receptor Gene Family.- Topology and Transmembrane Organization of Ryanodine Receptors.- Three-Dimensional Reconstruction of Ryanodine Receptors.- RYR-DHPR Relationships in Skeletal and Cardiac Muscles.- The Pore of the Ryanodine Receptor Channel.- Intra-Molecular Domain-Domain Interaction.- Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium.- Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels.- Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks.- Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes.- Stability and Instability of Ca2+ Release from the SR.- Ryanodine Receptors in Smooth Muscle.- Functions of RYR3 Homologues.- Knockout Mice Lacking RYR and Junctophilin Subtypes.- Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes.- RYR1 Modulation by Calmodulin.- Ryanodine Receptor Function in Inflammation.- Ryanoids, Receptor Affinity and RYR Channel Subconductance.- Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function.- Redox Sensing by the Ryanodine Receptors.- Ryanodine Receptor Dysfunction in the Diabetic Heart.- Molecular and Clinical Genetics of RYR1 Disorders.- Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor.- The Dantrolene Binding Site on RYR1.- Ryanodine Receptor Dysfunction in Heart Failure and Arrhythmias.- Stabilization of Ryanodine Receptor as a Novel Therapeutic Strategy Against Heart Failure.- Ryanodine Receptor Antibodies and Myasthenia Gravis.
Synopsis
Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions. David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School
LC Classification Number
RC666-701.2
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