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Product Identifiers
PublisherCRC Press LLC
ISBN-100849347564
ISBN-139780849347566
eBay Product ID (ePID)1066555
Product Key Features
Number of Pages448 Pages
LanguageEnglish
Publication NameRadioprotectors : Chemical, Biological, and Clinical Perspectives
SubjectIndustrial Health & Safety, Oncology, Radiology, Radiotherapy & Nuclear Medicine, Forensic Science
Publication Year1997
TypeTextbook
AuthorKamal Malaker, Edward A. Bump
Subject AreaLaw, Technology & Engineering, Medical
FormatHardcover
Dimensions
Item Height0.9 in
Item Weight34.7 Oz
Item Length9.3 in
Item Width6.1 in
Additional Product Features
Edition Number1
Intended AudienceScholarly & Professional
LCCN97-022136
Dewey Edition21
IllustratedYes
Dewey Decimal612.01448
Table Of ContentSECTION I -- CHEMICAL ASPECTS OF RADIOPROTECTION -- Introduction /Edward A. Bump -- Chapter 1 -- History of Radioprotector Development /William O. Foye -- Chapter 2 -- The Mechanisms of Radiation Protection by Non-Protein Sulfhydryls: Glutathione, Cysteine, and Cysteamine /Cameron J. Koch -- Chapter 3 -- Aminothiols /David Murray -- Chapter 4 -- Stable Free Radicals as Radiation Protectors /Stephen M. Hahn, C. Murali Krishna, and James B. Mitchell -- Chapter 5 -- Radioprotection by Superoxide Dismutase /Radha M. Das -- Chapter 6 -- DNA-Binding Bibenzimidazoles as Radioprotectors /Roger F. Martin -- Chapter 7 -- Protection against Radiation Damage to DNA Bases /Ali Laayoun, Jean Lhomme, Maurice Berger, and Jean Cadet -- SECTION II -- BIOLOGICAL PERSPECTIVES OF RADIOPROTECTION -- Introduction /William F. Blakely, Joseph F. Weiss, and Edward A. Bump -- Chapter 8 -- Eicosanoid-Induced Radioprotection and Chemoprotection: Laboratory Studies and Clinical Applications /Wayne R. Hanson -- Chapter 9 -- Immunomodulators and Cytokines: Their Use in the Mitigation of Radiation-Induced Hemopoietic Injury /Myra L. Patchen -- Chapter 10 -- Modulation of the Radiation Response by Cytokines /Ruth Neta -- Chapter 11 -- Radiation-Induced Apoptosis in Lymphoid Cells: Induction, Prevention, and Molecular Mechanisms /Narayani Ramakrishnan, John F. Kalinich, and David E. McClain -- Chapter 12 -- Modulation of Radiation-Induced Apoptosis /S. T. Palayoor, Ruth E. Langley, C. Norman Coleman, and Edward A. Bump -- Chapter 13 -- Chemoprevention with WR-2721 and Its Metabolites /Jeffrey S. Murley and David J. Grdina -- SECTION III RADIOPROTECTION OF NORMAL TISSUES -- Introduction /Elizabeth L. Travis -- Chapter 14 -- Protection against Radiation Damage to Vascular Tissues /Susan J. Braunhut -- Chapter 15 -- Radiation Protection in the Developing Central Nervous System: Investigation of a Biological Approach /Phyllis J. Mullenix -- Chapter 16 -- Clinical Experience with Radioprotectors /Kamal Malaker -- INDEX.
SynopsisIt is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection, It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
LC Classification NumberRA1231.R2R2847 1998
