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Computational Genetics und Genomics: Werkzeuge zum Verständnis von Krankheiten von Peltz-
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eBay-Artikelnr.:264901964975
Artikelmerkmale
- Artikelzustand
- Pages
- 307
- Publication Date
- 2005-04-01
- Topic
- Computers
- ISBN
- 9781588291875
Über dieses Produkt
Product Identifiers
Publisher
Humana Press
ISBN-10
1588291871
ISBN-13
9781588291875
eBay Product ID (ePID)
2320895
Product Key Features
Number of Pages
X, 308 Pages
Language
English
Publication Name
Computational Genetics and Genomics : Tools for Understanding Disease
Publication Year
2005
Subject
Life Sciences / Genetics & Genomics, Genetics
Type
Textbook
Subject Area
Science, Medical
Format
Hardcover
Dimensions
Item Weight
24.9 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2004-022878
Number of Volumes
1 vol.
Illustrated
Yes
Table Of Content
Theory and Technical Concept.- Computational Biology.- Statistical Theory in QTL Mapping.- Haplotype-Based Computational Genetic Analysis In Mice.- Haplotype Structure of the Mouse Genome.- SNP Discovery and Genotyping.- Selected Examples: Murine Models of Human Disease.- Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Models.- Murine Models of Osteoporosis.- Murine Models of Substance and Alcohol Dependence.- Murine Models of Alcoholism.- Selected Examples: The Genetic Basis for Human Disease.- HLA Polymorphism and Disease Susceptibility.- Asthma Genetics.
Synopsis
Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial., provides a novel perpective on how genetic and genomic tools can be used to understand complex disease; covers analysis of murine genetic models of human disease traits, as well as computational genetics analysis of human complex disease; could be considered as a textbook for advance undergraduate courses., Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases.
LC Classification Number
RB155-155.8
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