Dewey Edition20
Reviews'a multi-authored, comprehensive review of the hereditary cystic kidneydiseases ... There is useful information on virtually every page ... the book iswell organized and well referenced, with figures and graphs that clearly augmentthe written text ... This text makes a useful addition to the clinician'slibrary.'Bruce Z. Morgenstern, Pediatr Nephrol (1997) 11:664, 'I found this book a delight to read - it provides a balanced diet ofgenetics, pathophysiology and clinical medicine. For experts and researchers inthe field there is detailed information and stimulation; for interestedclinicians, the scientific sections are intelligibly presented and the clinicalsections should be a real aid in day-to-day practice. This book does not simplygive a list of known features or research in the condition it covers, it alsosquarely addresses some of the more difficult problems which face clincians andtheir patients.'Terry Feest, Southmead Hospital, Journal of the Royal College of Physicians ofLondon, Vol. 32, No. 1 January./February 1998, 'This is a further addition to the 'Oxford Clinical Nephrology' Series andprovides an extensive review of our current knowledge on polycystic kidneydisease...Overall this is an excellent book and provides much useful informationfor both the diagnosis and management of renal cystic diseases. It can be highlyrecommended, not just for the outstanding way the subject has been approached,but because the book also contains useful background information which greatlyenhances the overall value.'Nephrol Dial Transplant, 1998, 13: 1904-1908, 'a multi-authored, comprehensive review of the hereditary cystic kidney diseases ... There is useful information on virtually every page ... the book is well organized and well referenced, with figures and graphs that clearly augment the written text ... This text makes a useful addition tothe clinician's library.'Bruce Z. Morgenstern, Pediatr Nephrol (1997) 11:664, 'This is a further addition to the 'Oxford Clinical Nephrology' Series and provides an extensive review of our current knowledge on polycystic kidney disease...Overall this is an excellent book and provides much useful information for both the diagnosis and management of renal cystic diseases.It can be highly recommended, not just for the outstanding way the subject has been approached, but because the book also contains useful background information which greatly enhances the overall value.'Nephrol Dial Transplant, 1998, 13: 1904-1908, 'a multi-authored, comprehensive review of the hereditary cystic kidney diseases ... There is useful information on virtually every page ... the book is well organized and well referenced, with figures and graphs that clearly augment the written text ... This text makes a useful addition to the clinician's library.'Bruce Z. Morgenstern, Pediatr Nephrol (1997) 11:664'I found this book a delight to read - it provides a balanced diet of genetics, pathophysiology and clinical medicine. For experts and researchers in the field there is detailed information and stimulation; for interested clinicians, the scientific sections are intelligibly presented and the clinical sections should be a real aid in day-to-day practice. This book does not simply give a list of known features or research in the condition it covers, it alsosquarely addresses some of the more difficult problems which face clinicians and their patients.'Terry Feest, Southmead Hospital, Journal of the Royal College of Physicians of London, Vol. 32, No. 1 January./February 1998'I found this book a delight to read - it provides a balanced diet of genetics, pathophysiology and clinical medicine. For experts and researchers in the field there is detailed information and stimulation; for interested clinicians, the scientific sections are intelligibly presented and the clinical sections should be a real aid in day-to-day practice ... this book should be of wide interest. This book does not simply give a list of known features orresearch in the condition it covers, it also squarely addresses some of the more difficult problems which face clinicians and their patients.'Terry Feest, Journal of the Royal College of Physicians of London, Vol. 32, No. 1 January/February 1998'This is a further addition to the 'Oxford Clinical Nephrology' Series and provides an extensive review of our current knowledge on polycystic kidney disease...Overall this is an excellent book and provides much useful information for both the diagnosis and management of renal cystic diseases. It can be highly recommended, not just for the outstanding way the subject has been approached, but because the book also contains useful background information whichgreatly enhances the overall value.'Nephrol Dial Transplant, 1998, 13: 1904-1908, 'I found this book a delight to read - it provides a balanced diet of genetics, pathophysiology and clinical medicine. For experts and researchers in the field there is detailed information and stimulation; for interested clinicians, the scientific sections are intelligibly presented and theclinical sections should be a real aid in day-to-day practice. This book does not simply give a list of known features or research in the condition it covers, it also squarely addresses some of the more difficult problems which face clinicians and their patients.'Terry Feest, Southmead Hospital, Journal of the Royal College of Physicians of London, Vol. 32, No. 1 January./February 1998
Table Of ContentPart I: Cystic renal disease: experimental models and pathology1. Principles of molecular biology as applied to the study of disease2. In vitro models in the study of renal cystogenesis3. Mouse models of polycystic kidney disease4. In vivo models in non-murine species5. Pathogenesis of polycystic kidney disease: basement membrane and extracellular matric6. Pathogenesis of polycystic kidney disease: altered cellular functionPart II: Cystic renal disease: clinical spectrum7. Classification of cystic kidneys8. Diagnostic imaging of renal cystic diseases9. Autosomal recessive polycystic kidney disease: clinical and genetic profiles10. Acquired renal cystic disease11. Tuberous sclerosis complex12. Von Hippel-Lindau DiseasePart III: Adult polycystic kidney disease: natural history and genetics13. Definition and natural history of autosomal dominant polycystic kidney disease14. Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney diseasePart IV: Adult polycystic kidney disease: clinical features16. Hypertension in polycystic kidney disease17. Progression to renal insufficiency18. Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease19. Chronic pain and its medical and surgical management in renal cystic diseasePart V: Adult polycystic kidney disease: complications20. Miscellaneous renal and systemic complications of autosomal dominant polycystic kidney disease including infection21. Polycystic liver disease22. Intracranial aneurysms in autosomal dominant polycystic kidney disease23. Particular problems in childhood and adolescents in autosomal dominant polycystic kidney disease24. Counselling and ethical considerations in autosomal polycystic kidney disease
SynopsisMany inherited diseases and non-herediatry disorders have in common th e development of renal cyctic disease. The most common, autosonal domi nant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the public ation six years ago of the last book on polycystic kidney disease, a n umber of genes causing the disease have been identified, mapped, or se quenced; new experimental models and the application of molecular biol ogy techniques have provided new insights into the pathogenesis of pol ycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the compl ications of this disease. This book provides an updated, state-of-the- art review of the genetics, pathophysiology, evaluation, and managemen t of these diseases and will be of interest to both basic researchers and clinicians in nephrology., Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology., Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology., Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology., Autosomal dominant polycystic kidney disease is thought to be the commonest disorder inherited autosomally. It is responsible for up to a tenth of all cases of end-stage renal disease and may also cause secondary disorders with a fatal outcome. Understanding of the causes and treatment has advanced rapidly in the last decade, and this book gives a state-of-the-art review of the diseases. It covers a wide range of topics in the natural history, diagnosis, clinical management, underlying genetic investigations, and family counselling of those with polycystic kidney disease, and will be of interest to clinical and research nephrologists worldwide.