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Process Chemistry in the Pharmaceutical Industry ~
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eBay-Artikelnr.:185742131109
Artikelmerkmale
- Artikelzustand
- Book Title
- Process Chemistry in the Pharmaceutical Industry
- Subject
- Chemistry
- ISBN
- 9780824719814
Über dieses Produkt
Product Identifiers
Publisher
CRC Press LLC
ISBN-10
0824719816
ISBN-13
9780824719814
eBay Product ID (ePID)
1165981
Product Key Features
Number of Pages
500 Pages
Language
English
Publication Name
Process Chemistry in the Pharmaceutical Industry
Publication Year
1999
Subject
Industries / Pharmaceutical & Biotechnology, Pharmacology, Chemistry / Industrial & Technical, Chemistry / General
Type
Textbook
Subject Area
Science, Business & Economics, Medical
Format
Hardcover
Dimensions
Item Height
1.3 in
Item Weight
38.6 Oz
Item Length
10.4 in
Item Width
7.2 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
99-026854
Reviews
"...the book successfully achieves its goal of presenting the basic principles and challenges associated with the discovery and scale-up of a commercial manufacturing process of a new drug." -- Journal of Medicinal Chemistry "...gives a thorough overview of the challenges facing the modern development chemists in the pharmaceutical industry. It can be recommended to any graduates or postgraduates considering a career in this fascinating field, and even old hands will find much stimulating chemistry in the case studies. " -- Organic Process Research & Development "...provides a good overview for those wanting an introduction to the science conducted in a process research group. For experienced process chemists, frequent descriptions of creative solutions to difficult problems makes the book worth reading ." -- Journal of the American Chemical Society "... recommended without reservation . It is suitable not only for the process chemist but also for those involved in preparative work in research in teaching, and for advanced students. It should find a place in every chemical library ." -- Angewandte Chemie "... presents pharmaceutical synthesis at its best in a very concise and educational way . The wealth of references and illustrations, and the carefully compiled subject index guarantees fast access to further information....the lively style in which chapters are written keeps the reader interested along the way." -- European Journal of Pharmaceutics and Biopharmaceutics, 2000
Illustrated
Yes
Table Of Content
Overview Process Chemistry in the Pharmaceutical Industry: An Overview , Kumar G. Gadamasetti Strategy Process Research and Development Strategy for Accelerated Projects , Christopher M. Cimarusti Case Studies A Practical Synthesis of Ifetroban Sodium , Richard H. Mueller Synthesis of 5-Lipoxygenase Inhibitors , Ivan Lantos and Richard Matsuoka Chemistry of Vitamin D: A Challenging Field for Process Research , Masami Okabe A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator , Hans-Jürgen Federsel and Edib Jakupovic Ontazolast: The Evolution of a Process , Vittorio Farina, Karl Grozinger, Hermann Müller-Bötticher and Gregory P. Roth Dilevalol Hydrochloride: Development of a Commercial Process , Derek Walker Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist , Michael J. Martinelli and David L. Varie Process Research and Development of CGS 19755, an NMDA Antagonist , Peter Giannousis, John Carlson and Marius Leimer Route Evaluation for the Production of (R)-Levoprotiline , H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter The Process Research and Development of DuPont Merck's Cyclic Urea Diols, A New Class of HIV Protease Inhibitors , Pat N. Confalone and Robert E. Waltermire Practical Enantio- and Diastereo-selective Processes for Azetidinones , T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors , Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen Enzymatic Intervention and Phase Transfer Catalysis Chemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164 , Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. Zmijewski Benefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry , Marc E. Halpern Asymmetric Synthesis and Enantioselectivity Enantioselective Synthesis: The Optimum Process , John J. Partridge and Brian L. Bray Practical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D - and L - Amino Acids , Timothy A. Ayers and T. V. Rajan Babu Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis -Aminoindanol and Its Application to Enantiopure Drug Synthesis , Chris H. Senanayake and Eric N. Jacobsen Drug Substance Final Form and Process Safety Chemical Development of the Drug Substance Solid Form , Michael D. Thompson and Jean-René Authelin The Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists , Wilfried Hoffmann Design of Experiments and Automation Using Factorial Experiments in the Development of Process Chemistry , Daniel R. Pilipauskas Laboratory Automation in Chemical Development , Martin R. Owen and Sheila H. Dewitt
Synopsis
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development , this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers--offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines., An ideal guide for scientists entering pharmaceutical discovery and development, this reference also clarifies the roles of various specialties in of new drug development. Featuring contributions from nearly 50 renowned researchers and over 1000 references, tables, and illustrations, it offers a solid grounding in synthetic as well asphysical organic chemistry. This seminal volume highlights new strategies for aggressive drug development programs, green synthesis processes, and other trends in the industry. It illustrates the impact of non-traditional small molecules as a therapeutic agent, including 12 case studies on agents such as inhibitors and antangonists.
LC Classification Number
RS403.P765 1999
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