MOMENTAN AUSVERKAUFT
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Product Identifiers
PublisherCambridge University Press
ISBN-100521183057
ISBN-139780521183055
eBay Product ID (ePID)4038301215
Product Key Features
Number of Pages394 Pages
LanguageEnglish
Publication NameCellular Biophysics and Modeling : a Primer on the Computational Biology of Excitable Cells
Publication Year2019
SubjectLife Sciences / Cell Biology, Life Sciences / Biophysics, Physiology
TypeTextbook
Subject AreaScience, Medical
AuthorGreg Conradi Smith
FormatTrade Paperback
Dimensions
Item Height0.8 in
Item Weight27.6 Oz
Item Length9.7 in
Item Width6.9 in
Additional Product Features
Intended AudienceCollege Audience
LCCN2018-039283
ReviewsAdvance praise: 'In this text, Conradi Smith does an excellent job of teaching students with no mathematical trainingbeyond calculus how to use differential equations to understand the basic principles of cell physiology and excitability.He skilfully walks students through the steps of modeling and analysis, all the while working to develop intuition and insight into how things work. His emphasis oncomputational methods for solution as well as graphical and geometrical means for interpretation enables him to communicate complex ideas in understandable ways. Furthermore, his patience and attention to detail will be appreciated by those students who have not had extensive exposure to the art of mathematical modeling. This text is a wonderful addition to the mathematical biology textbook literature.' James P. Keener, University of Utah
Dewey Edition23
IllustratedYes
Dewey Decimal612.014
Table Of Content1. Introduction; Part I. Models and Odes: 2. Compartmental modeling; 3. Phase diagrams; 4. Ligands, receptors and rate laws; 5. Function families and characteristic times; 6. Bifurcation diagrams of scalar ODEs; Part II. Passive Membranes: 7. The Nernst equilibrium potential; 8. The current balance equation; 9. GHK theory of membrane permeation; Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents; 11. Regenerative ionic currents and bistability; 12. Voltage-clamp recording; 13. Hodgkin-Huxley model of the action potential; Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model; 15. Phase plane analysis; 16. Linear stability analysis; Part V. Oscillations and Bursting: 17. Type II excitability and oscillations; 18. Type I excitability and oscillations; 19. The low-threshold calcium spike; 20. Synaptic currents.
SynopsisAn integrated guide to cellular biophysics and nonlinear dynamics, introducing students to the mathematical modeling of excitable cells. It combines empirical physiology and mathematical theory to present key interdisciplinary tools, highlighting how quantitative approaches can complement and advance bench research., What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.
LC Classification NumberQP363.S595 2019
