Severe malaria is a leading parasitic cause of mortality among humans, accounting for nearly 3 million annual deaths globally. As shown in different studies across Africa, morbidity pattern varies according to factors like age, geographic location and population genetics. This book describes the presentation of severe malaria at the time of admission, and the prevalence and determinants of clinical symptoms in hospitalized Ghanaian children. The findings would aid early recognition, diagnosis and treatment of the disease. Secondly, introduction of the Artemisinin-based Combination Therapy (ACT) policy in Ghana has come with reports of associated adverse drug reactions largely contributing to non- compliance. In spite of monitoring exercises, data regarding adverse antimalarial treatment-related reactions among Ghanaian children remains sketchy. This book thus provides an assessment of severe malaria pharmacotherapy and its related adverse reactions in hospitalized Ghananian children. The overall information presented in this book should be interesting read for health professionals, malaria researchers and anyone with an interest in malaria.