There are several types of medications that are used to manage a variety of diseases involving the oral cavity (mouth) that are part of good dental care. The medications discussed in this book have pharmacological properties that are used to treat conditions such as pain, anxiety, and infections, amongst others. It is notable that few of the drugs are in various phases of clinical trial and some awaiting final regulatory approvals. We can expect these antibacterials and analgesics to be soon present in market for the treatment of resistant strains once they gain the FDA approval. There is urgent need for complete understanding of the various aspects of drug resistance in microbes which can help in the choice of good targets, vital for discovery of drugs.