If a protein component including other necessary things that are needed for the cell to carry out various interactions with other immune cells then proteases will not be able to cleave it because normal living cells also contain an inhibitor mechanism that stops the cleaving process. Generally, protease insufficiency can cause many health related problems e.g. acidity create in the stomach through digestion of protein material; if there are not enough proteases then this acidic equilibrium is disconnected causing an enlargement in alkaline disposition in the blood which could lead to insomnia. Number of proteases are available or still under investigation or in clinical trials. There has been considerable attention to those proteases derived from micro-organisms including plant products that has been given to screening for possible anti-viral, anti-diabetic activity etc. In addition, researchers focused on plant products especially leaves and flowers that have formed the the basis of traditional medicine systems and continued to play an essential role or showed its necessity for human health care.