The monograph discusses the features of the development of small business and entrepreneurship in the national economy of Uzbekistan. There was analyzed the strategy and mechanisms of interaction between small and large businesses, and developed the strategy development of business support in the Fergana region as well as a set of scientific and practical recommendations to help improve the efficiency of its operation. The author analyzes the institutional regulation of small and private businesses in the US and the UK. Based on the index of the World Bank «Doing Business», there were calculated the effective regulation of the business environment in Uzbekistan and the creation of competitive relations of private entrepreneurs. The book is intended for students, senior researchers, anyone interested in entrepreneurship and economic aspects of functioning of small private businesses. Responsible Editor: professor of the Russian Academy of Natural Sciences, PhD in economics Kurpayanidi K. I.