Photon detectors are used for various kinds of experiments in the field of nuclear physics. The response function of photon detectors on gamma rays is complex and needs to be considered during the analysis of experimental data. This thesis experimentally investigates such response functions for different detector types in a large energy range (2 - 20 MeV). The experiments described in this thesis were performed at the NEPTUN photon tagging facility, which provides a mono energetic photon source with tunable energy and intensity. As these were the first experiments to be performed at NEPTUN, within this study extensive development and commissioning of the setup also with respect to future campaigns were accomplished. The setup is shown to be well suited for the systematic study of detector response functions, while measurements of nuclear reactions need further improvements.
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