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- KurzbeschreibungA realistic deterministic demographic model that <br>captures the pattern of inheritance of the gene <br>responsible for the most common genetic defect is <br>formulated using general pair formations and <br>analyzed using various approaches including a <br>numerical semi-discretization scheme. The patterns <br>of inheritance of the disease are carefully derived. <br>Polygamy is captured in the application and it is <br>shown to be partially responsible for the widespread <br>of this defect.<br>This book is therefore a basic introduction to the <br>mathematics of SCA at the population level, taking <br>into account the genotype of individuals in the <br>mating pattern. Minimizing mating which produces SCA <br>sufferers can theoretically be achieved if some <br>carriers of the trait as well as SCA patients agree <br>to remain childless or choose celibacy (a difficult <br>social condition indeed!). The analysis helps shed <br>some light on this genetic defect and should be <br>especially useful to senior undergraduates and <br>graduate students as well as scientists working at <br>the interface between mathematics and biological <br>sciences interested in genetically transmitted <br>disorders.
- AutorJean M. Tchuenche
- Seiten68 Seiten
- Gewicht108 g
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